Magnetic Nanoparticles

Magnetic Relaxation
Magnetic nanoparticles in medicine

The magnetic nanoparticles group is a consolidated subgroup of the Magnetic Resonance Division that began its activity in 1994 under the supervision of Dr. Roberto Zysler. It carries out its research on magnetic nanoparticles for both basic and applied physics. Nowadays, the group is composed by several permanent researchers with different fields of expertise. Strongly focused on the basic and applied research on magnetic nanoparticles, the group is also focused on human research training, from undergraduate, masters, PhD students in Physics, Medical Physics and Engineering to post-doc, but also including short-term graduate interns or special formation programs. The different research lines on magnetic nanoparticles (MNPs) encompass from basic research on their properties to applications in bio-medicine and environmental remediation.
We design and synthesize different MNPs systems, including some novel ones, tuning their properties by modifying their composition, size, inter-particle interactions and intra-particle interactions using distinct morphological architectures (core/shell systems, surface effects). In addition to the design and synthesis, our studies include the characterization of the MNPs systems. As part of this characterization, their magnetic responses are modeled using proposed analytical models and numerical simulations. Since 2004, we are involved in different studies on the applications of MNPs, mainly focused on magnetic fluid hyperthermia as a potential cancer treatment; the peroxidase-type activity to catalyze the production of free radicals for medical applications and environmental remediation; and the development of medical treatments, as an alternative treatment for retinal detachment. These applications involve the study of the uptake and toxicity of nanoparticles in cultured cells, and how these two processes depend on the different functionalization of MNPs.

Areas of impact of the research group
– Magnetic monodomains
– Magnetic anisotropy
– Magnetization relaxation
– Exchange bias
– Hard magnetic materials – Permanent magnets
– Soft magnetic materials
– Magnetic nanoparticles in medicine
– Magnetic fluid hyperthermia
– Drug delivery
– Catalytic activity for Free radicals production
– Reactive oxygen species
– Environment remediation

Researchers
– Dr. Emilio De Biasi
Dr. Enio Lima Jr.
– Dr. Marcela Nadal
Dr. Mariana Raineri
– Dr. Carlos Ramos
– Dr. Dina Tobia
Dr. Marcelo Vasquez Mansilla
Dr. Elin Winkler
Dr. Roberto Zysler